Description
mRNA turnover protein 4 homolog, also known as MRTO4, belongs to the ribosomal protein L10P family. MRTO4 is a nucleolar component of the ribosome assembly machinery that shares notable similarity and competes for binding to the 25S rRNA GAR domain with the ribosomal protein P0. The gene encoding MRTO4 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Recombinant human MRTO4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques